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GLP-1 RA therapy Molecular design Method of absorption video GLP-1 RA therapy Molecular design Method of absorption video How RYBELSUS works RYBELSUS , like other GLP-1 RAs, mimics the bodys native GLP-1 hormone to respond to elevated levels of blood glucose, working when the body needs it 1 RYBELSUS works differently than any other diabetes pill to lower blood sugar in the following 3 ways 1,2 GLP-1 RAs reduce blood glucose by stimulating insulin secretion and lowering glucagon secretion, both in a glucose-dependent manner RYBELSUS is a GLP-1 analog with 94% similarity to human GLP-1 1 Structural modifications of the RYBELSUS molecule prevent degradation by DPP-4 and prolong incretin activity

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